diff --git a/app/_layout.tsx b/app/_layout.tsx
index c776a2c..e871cd8 100644
--- a/app/_layout.tsx
+++ b/app/_layout.tsx
@@ -1,7 +1,7 @@
 import '@/i18n';
 import { DefaultTheme, ThemeProvider } from '@react-navigation/native';
 import { useFonts } from 'expo-font';
-import { Stack } from 'expo-router';
+import { Stack, useRouter } from 'expo-router';
 import { StatusBar } from 'expo-status-bar';
 import { GestureHandlerRootView } from 'react-native-gesture-handler';
 import 'react-native-reanimated';
@@ -19,7 +19,7 @@ import { WaterRecordSource } from '@/services/waterRecords';
 import { workoutMonitorService } from '@/services/workoutMonitor';
 import { store } from '@/store';
 import { hydrateActiveSchedule, selectActiveFastingSchedule } from '@/store/fastingSlice';
-import { fetchMyProfile, setPrivacyAgreed } from '@/store/userSlice';
+import { fetchMyProfile, logout, setPrivacyAgreed } from '@/store/userSlice';
 import { createWaterRecordAction } from '@/store/waterSlice';
 import { loadActiveFastingSchedule } from '@/utils/fasting';
 import { initializeHealthPermissions } from '@/utils/health';
@@ -31,7 +31,7 @@ import { DialogProvider } from '@/components/ui/DialogProvider';
 import { MembershipModalProvider } from '@/contexts/MembershipModalContext';
 import { ToastProvider } from '@/contexts/ToastContext';
 import { useAuthGuard } from '@/hooks/useAuthGuard';
-import { STORAGE_KEYS } from '@/services/api';
+import { STORAGE_KEYS, setUnauthorizedHandler } from '@/services/api';
 import { BackgroundTaskManager } from '@/services/backgroundTaskManagerV2';
 import { fetchChallenges } from '@/store/challengesSlice';
 import AsyncStorage from '@/utils/kvStore';
@@ -52,6 +52,7 @@ if (__DEV__) {
 
 function Bootstrapper({ children }: { children: React.ReactNode }) {
   const dispatch = useAppDispatch();
+  const router = useRouter();
   const { profile, onboardingCompleted } = useAppSelector((state) => state.user);
   const activeFastingSchedule = useAppSelector(selectActiveFastingSchedule);
   const [showPrivacyModal, setShowPrivacyModal] = React.useState(false);
@@ -62,6 +63,28 @@ function Bootstrapper({ children }: { children: React.ReactNode }) {
   // 初始化快捷动作处理
   useQuickActions();
 
+  // 注册401未授权处理器（应用启动时执行一次）
+  React.useEffect(() => {
+    const handle401 = async () => {
+      try {
+        logger.info('[401处理] 开始处理登录过期');
+        
+        // 清除Redux状态
+        await dispatch(logout());
+        
+        // 跳转到登录页
+        router.push('/auth/login');
+        
+        logger.info('[401处理] 登录过期处理完成');
+      } catch (error) {
+        logger.error('[401处理] 处理失败:', error);
+      }
+    };
+
+    setUnauthorizedHandler(handle401);
+    logger.info('[401处理器] 已注册到API服务');
+  }, [dispatch, router]);
+
   React.useEffect(() => {
     if (fastingHydrationRequestedRef.current) return;
     if (activeFastingSchedule) {
diff --git a/services/api.ts b/services/api.ts
index 74316c7..44bbd02 100644
--- a/services/api.ts
+++ b/services/api.ts
@@ -1,8 +1,87 @@
 import { buildApiUrl } from '@/constants/Api';
 import AsyncStorage from '@/utils/kvStore';
+import { Alert } from 'react-native';
 
 type HttpMethod = 'GET' | 'POST' | 'PUT' | 'PATCH' | 'DELETE';
 
+// 401处理的防抖机制
+let is401Handling = false;
+let last401Time = 0;
+const DEBOUNCE_INTERVAL = 3000; // 3秒内只处理一次401
+
+// 401处理回调函数（由应用层注册）
+type UnauthorizedHandler = () => void | Promise<void>;
+let unauthorizedHandler: UnauthorizedHandler | null = null;
+
+/**
+ * 注册401未授权处理器
+ * 应该在应用启动时调用，传入退出登录的函数
+ */
+export function setUnauthorizedHandler(handler: UnauthorizedHandler) {
+  unauthorizedHandler = handler;
+  console.log('[API] 401处理器已注册');
+}
+
+/**
+ * 统一处理401未授权错误
+ * 包含防抖机制，避免多次提示
+ */
+async function handle401Unauthorized() {
+  const now = Date.now();
+  
+  // 防抖：如果正在处理或者距离上次处理不到3秒，直接返回
+  if (is401Handling || (now - last401Time < DEBOUNCE_INTERVAL)) {
+    console.log('[API] 401处理防抖，跳过重复处理');
+    return;
+  }
+  
+  is401Handling = true;
+  last401Time = now;
+  
+  try {
+    console.log('[API] 检测到401未授权，开始处理登录过期');
+    
+    // 清除本地token
+    await AsyncStorage.removeItem(STORAGE_KEYS.authToken);
+    await setAuthToken(null);
+    
+    // 提示用户
+    Alert.alert(
+      '登录已过期',
+      '您的登录状态已过期，请重新登录',
+      [
+        {
+          text: '确定',
+          onPress: () => {
+            console.log('[API] 用户确认登录过期提示');
+            // 调用注册的处理器（如果存在）
+            if (unauthorizedHandler) {
+              try {
+                const result = unauthorizedHandler();
+                if (result instanceof Promise) {
+                  result.catch(err => {
+                    console.error('[API] 401处理器执行失败:', err);
+                  });
+                }
+              } catch (err) {
+                console.error('[API] 401处理器执行失败:', err);
+              }
+            }
+          }
+        }
+      ],
+      { cancelable: false }
+    );
+  } catch (error) {
+    console.error('[API] 处理401错误时发生异常:', error);
+  } finally {
+    // 延迟重置处理标志，确保不会立即再次触发
+    setTimeout(() => {
+      is401Handling = false;
+    }, 1000);
+  }
+}
+
 let inMemoryToken: string | null = null;
 
 export async function setAuthToken(token: string | null): Promise<void> {
@@ -52,6 +131,12 @@ async function doFetch<T>(path: string, options: ApiRequestOptions = {}): Promis
   console.log('json', json);
 
   if (!response.ok) {
+    // 检查是否为401未授权
+    if (response.status === 401) {
+      console.log('[API] 检测到401状态码，触发登录过期处理');
+      await handle401Unauthorized();
+    }
+    
     const errorMessage = (json && (json.message || json.error)) || `HTTP ${response.status}`;
     const error = new Error(errorMessage);
     // @ts-expect-error augment
@@ -181,7 +266,15 @@ export async function postTextStream(path: string, body: any, callbacks: TextStr
       try { console.log('[AI_CHAT][stream] done', { status: xhr.status }); } catch { }
       if (!resolved) {
         cleanup();
-        if (xhr.status >= 200 && xhr.status < 300) {
+        if (xhr.status === 401) {
+          // 处理401未授权
+          console.log('[AI_CHAT][stream] 检测到401状态码，触发登录过期处理');
+          handle401Unauthorized().catch(err => {
+            console.error('[AI_CHAT][stream] 处理401错误时发生异常:', err);
+          });
+          const error = new Error('登录已过期');
+          try { callbacks.onError?.(error); } catch { }
+        } else if (xhr.status >= 200 && xhr.status < 300) {
           try { callbacks.onEnd?.(conversationIdFromHeader); } catch { }
         } else {
           const error = new Error(`HTTP ${xhr.status}`);